Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, with more than 5 million patients in China. The cardinal symptoms of PD are motor dysfunctions, including resting tremor, bradykinesia, and rigidity, which are attributed to the progressive loss of dopaminergic neurons in the substantia nigra.
Lineage reprograming of resident astrocyte into functional neuron holds great promise and is a currently hotspot for neurological disease therapy.
Drug discovery and development have huge potential benefits for the pharmaceutical industry and patients. The identification of wet-lab experiment technology is expensive and time-consuming. Therefore, the use of artificial intelligence methods to identify potential drugs can significantly reduce costs and greatly shorten the drug development process.
On June 1, 2022, an original article was published online by Prof. Xiulan Zhang’s team in Journal of Clinical Investigation (JCI, IF=19.3) on predicting the incidence and progression of glaucoma based on color fundus photos using artificial intelligence (AI). This is the 11th publication focusing on glaucoma AI after a series of works published in NPJ Digital Medicine,Ophthalmology, and Medica...
Microbes are indispensable components for the key biological processes of estuarine ecosystems and three main habitats (sediment, particle, and water) are harboring diverse estuarine microbes that prefer distinct lifestyles, such as the free-living (FL) and particle-attached (PA) microbes in water column and the benthic microbes in the sediment.
Antibiotics were one of the most important discoveries in the history of medicine during the 20th century. Antibiotic resistance, however, has become a major concern worldwide due to antibiotic abuse or misuse. As a genetic phenomenon, antibiotic resistance occurs when bacteria evolve in response to selective pressures imposed by antibiotics.
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